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Complex mechanisms behind anaemia of CKD

Watch the latest discussion from the experts

The mechanisms involved in anaemia of chronic kidney disease (CKD) are diverse and complex. They include¹:

Reduced erythropoietin production

Absolute iron deficiency due to blood losses or impaired iron absorption

Inefficient use of iron stores due to inflammation with increased hepcidin levels

Inflammation due to CKD and associated comorbidities

Reduced bone marrow response to erythropoietin due to uremic toxins

Interview with nephrologist about the mechanisms behind anaemia of CKD

Interview with nephrologist about the prevalence, severity, and symptoms of anaemia of CKD.

Learn more about the consequences of anaemia of CKD and how patients rely on nephrologists and nurses.

Nephrologist shares her thoughts on the key challenges in managing anaemia in CKD and her hopes for the future.

Nephrology nurse shares her tips for the structured conversation with patients and their families about anaemia

“Nephrologists and nurses play an important role in detecting

and treating anaemia in their CKD patients”

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about nephrology and anaemia of CKD?

1 in 5 CKD patients develop anaemia²

Anaemia of CKD generally increases in frequency and severity in the more advanced stages of CKD.³

Anaemia of CKD can:

Reduce health-related quality of life4

Increase cardiovascular risk5

Increase the risk of all-cause mortality6

Accelerate the progression of CKD7

Patient stories: How anaemia of CKD can impact patients’ lives

Two patients tell their stories about how anaemia of CKD impacts their lives.

The multiple pathological mechanisms behind anaemia of CKD

Learn more about the complex pathological mechanisms that contribute to aneamia in CKD.


Take the challenge and gain new insights about anaemia in CKD patients

Anaemia could be consuming patients with advanced CKD. Not only in terms of physical impact, but also in terms of impared quality of life.

The questions in this quiz are based on the findings in published studies.3,4,6


1. Portolés J, et al. Anemia in Chronic Kidney Disease: From Pathophysiology and Current Treatments, to Future Agents. Front Med (Lausanne). 2021;8:642296.
2. Dmitrieva O, et al. Association of anaemia in primary care patients with chronic kidney disease: cross sectional study of quality improvement in chronic kidney disease (QICKD) trial data. BMC Nephrol. 2013;14:24.
3. Evans M, et al. Contemporary management of anaemia, erythropoietin resistance and cardiovascular risk in patients with advanced chronic kidney disease: a nationwide analysis. Clin Kidney J. 2020;13(5):821-827.
4. Eriksson D, et al. Cross-sectional survey in CKD patients across Europe describing the association between quality of life and anaemia. BMC Nephrol. 2016;17(1):97.
5. Weiner DE, et al. Effects of anemia and left ventricular hypertrophy on cardiovascular disease in patients with chronic kidney disease. J Am Soc Nephrol. 2005;16(6):1803-1810.
6. Astor BC, et al. Kidney function and anemia as risk factors for coronary heart disease and mortality: the Atherosclerosis Risk in Communities (ARIC) Study. Am Heart J. 2006;151(2):492-500.
7. Mohanram A, et al. Anemia and end-stage renal disease in patients with type 2 diabetes and nephropathy. Kidney Int. 2004;66(3):1131-1138.