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Complex mechanisms behind anaemia of CKD
Watch the latest discussion from the experts
The mechanisms involved in anaemia of chronic kidney disease (CKD) are diverse and complex. They include¹:
Reduced erythropoietin production
Absolute iron deficiency due to blood losses or impaired iron absorption
Inefficient use of iron stores due to inflammation with increased hepcidin levels
Inflammation due to CKD and associated comorbidities
Reduced bone marrow response to erythropoietin due to uremic toxins
Interview with nephrologist about the mechanisms behind anaemia of CKD
Interview with nephrologist about the prevalence, severity, and symptoms of anaemia of CKD.
Learn more about the consequences of anaemia of CKD and how patients rely on nephrologists and nurses.
Nephrologist shares her thoughts on the key challenges in managing anaemia in CKD and her hopes for the future.
Nephrology nurse shares her tips for the structured conversation with patients and their families about anaemia
“Nephrologists and nurses play an important role in detecting
and treating anaemia in their CKD patients”
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about nephrology and anaemia of CKD?
1 in 5 CKD patients develop anaemia²
Anaemia of CKD generally increases in frequency and severity in the more advanced stages of CKD.³
Anaemia of CKD can:
Reduce health-related quality of life4
Increase cardiovascular risk5
Increase the risk of all-cause mortality6
Accelerate the progression of CKD7
Patient stories: How anaemia of CKD can impact patients’ lives
Two patients tell their stories about how anaemia of CKD impacts their lives.
The multiple pathological mechanisms behind anaemia of CKD
Learn more about the complex pathological mechanisms that contribute to aneamia in CKD.
Take the challenge and gain new insights about anaemia in CKD patients
Anaemia could be consuming patients with advanced CKD. Not only in terms of physical impact, but also in terms of impared quality of life.
The questions in this quiz are based on the findings in published studies.3,4,6
1. Portolés J, et al. Anemia in Chronic Kidney Disease: From Pathophysiology and Current Treatments, to Future Agents. Front Med (Lausanne). 2021;8:642296.
2. Dmitrieva O, et al. Association of anaemia in primary care patients with chronic kidney disease: cross sectional study of quality improvement in chronic kidney disease (QICKD) trial data. BMC Nephrol. 2013;14:24.
3. Evans M, et al. Contemporary management of anaemia, erythropoietin resistance and cardiovascular risk in patients with advanced chronic kidney disease: a nationwide analysis. Clin Kidney J. 2020;13(5):821-827.
4. Eriksson D, et al. Cross-sectional survey in CKD patients across Europe describing the association between quality of life and anaemia. BMC Nephrol. 2016;17(1):97.
5. Weiner DE, et al. Effects of anemia and left ventricular hypertrophy on cardiovascular disease in patients with chronic kidney disease. J Am Soc Nephrol. 2005;16(6):1803-1810.
6. Astor BC, et al. Kidney function and anemia as risk factors for coronary heart disease and mortality: the Atherosclerosis Risk in Communities (ARIC) Study. Am Heart J. 2006;151(2):492-500.
7. Mohanram A, et al. Anemia and end-stage renal disease in patients with type 2 diabetes and nephropathy. Kidney Int. 2004;66(3):1131-1138.